Alice Lotion 60gm

COMPOSITION Alice™ Lotion: Each gram of lotion contains Ivermectin BP 0.5%

PHARMACOLOGY Ivermectin, a member of the Avermectin class, causes death of parasites, primarily through binding selectively and with high a nity to glutamate-gated chloride channels, which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The selective activity of compounds of this class is attributable to the fact that some mammals do not have glutamate-gated chloride channels, the Avermectins have a low a nity for mammalian ligand-gated chloride channels, and Ivermectin does not readily cross the blood-brain barrier in humans.

INDICATION It is indicated for the topical treatment of head lice infestations in patients 6 months of age and older.

DOSAGE AND ADMINISTRATION Only for topical use in scalp & scalp hair. It is not for oral, ophthalmic, or intravaginal use.

Alice™ Lotion should be applied to dry hair in an amount sufficient to thoroughly coat the hair and scalp. Keep lotion on the hair and scalp for 10 minutes, and then rinse o with water.

The tube is intended for single use. Contact with eyes should be avoided.

CONTRAINDICATION None

PRECAUTION In order to prevent ingestion, it should only be administered to pediatric patients under the direct supervision of an adult. In case of accidental poisoning, supportive therapy, if indicated, should include parenteral fluids and electrolytes, respiratory support (oxygen and mechanical ventilation if necessary) and pressor agents if clinically significant hypotension is present. Induction of emesis and/or gastric lavage as soon as possible, followed by purgatives and other routine anti-poison measures, may be indicated if needed to prevent absorption of ingested material.

SIDE EFFECT Conjunctivitis, Ocular hyperemia, Eye irritation, Dandruff, Dry skin, skin burning sensation etc.

USE IN PREGNANCY & LACTATION Pregnancy Category C There are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential bene justifies the potential risk to the fetus. Caution should be exercised when this lotion is administered to a nursing woman.

STORAGE CONDITION Keep it out of reach of children. Keep away from light and Store below 30° C.

WHAT A SUPPLIED Alice™ Lotion: Each pack has a laminated tube containing 60 gm lotion.

Keep away from light & wet place. Keep out of reach of children.

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